Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90

Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90 Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Discovery and development of heat shock protein 90 inhibitors Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone From Bacteria to Cancer: A Benzothiazole-Based DNA Gyrase B Inhibitor Redesigned for Hsp90 C-Terminal Inhibition Adenine derived inhibitors of the molecular chaperone HSP90—SAR explained through multiple X-ray structures Discovery of (2,4-Dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a Novel Inhibitor of the Molecular Chaperone Hsp90 by Fragment Based Drug Design Novel, Potent Small-Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered through Structure-Based Design