Novel, Potent, and Selective Quinoxaline-Based 5-HT₃Receptor Ligands. 1. Further Structure−Activity Relationships and Pharmacological Characterization

Novel, Potent, and Selective Quinoxaline-Based 5-HT₃Receptor Ligands. 1. Further Structure−Activity Relationships and Pharmacological Characterization Specific Targeting of Peripheral Serotonin 5-HT₃Receptors. Synthesis, Biological Investigation, and Structure−Activity Relationships Novel Potent and Selective Central 5-HT₃ Receptor Ligands Provided with Different Intrinsic Efficacy. 1. Mapping the Central 5-HT₃ Receptor Binding Site by Arylpiperazine Derivatives Novel and Highly Potent 5-HT₃ Receptor Agonists Based on a Pyrroloquinoxaline Structure Novel Potent and Selective Central 5-HT₃ Receptor Ligands Provided with Different Intrinsic Efficacy. 2. Molecular Basis of the Intrinsic Efficacy of Arylpiperazine Derivatives at the Central 5-HT₃ Receptors Pyrroloquinoxaline Derivatives as High-Affinity and Selective 5-HT₃ Receptor Agonists:  Synthesis, Further Structure−Activity Relationships, and Biological Studies Novel and Selective Partial Agonists of 5-HT₃ Receptors. 2. Synthesis and Biological Evaluation of Piperazinopyridopyrrolopyrazines, Piperazinopyrroloquinoxalines, and Piperazinopyridopyrroloquinoxalines Further Studies on the Interaction of the 5-Hydroxytryptamine₃(5-HT₃) Receptor with Arylpiperazine Ligands. Development of a New 5-HT₃Receptor Ligand Showing Potent Acetylcholinesterase Inhibitory Properties Novel, Potent, and Selective 5-HT3 Receptor Antagonists Based on the Arylpiperazine Skeleton: Synthesis, Structure, Biological Activity, and Comparative Molecular Field Analysis Studies N-(quinuclidin-3-YL)-1,8,-naphthalimides with 5-HT3 receptor antagonist and 5-HT4 receptor agonist properties