Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration

Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration Tetrahydroquinoline and tetrahydroisoquinoline derivatives as potential selective PDE4B inhibitors Synthesis and SAR Studies of 1H-Pyrrolo[2,3-b]pyridine-2-carboxamides as Phosphodiesterase 4B (PDE4B) Inhibitors Novel indolizine compounds as potent inhibitors of phosphodiesterase IV (PDE4): structure–activity relationship Design, synthesis and in vitro PDE4 inhibition activity of certain quinazolinone derivatives for treatment of asthma Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction Structure-based design and structure-activity relationships of 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors Design, synthesis and biological evaluation of novel tetrahydroisoquinoline derivatives as potential PDE4 inhibitors Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors Discovery of novel inhibitors of phosphodiesterase 4 with 1-phenyl-3,4-dihydroisoquinoline scaffold: Structure-based drug design and fragment identification