A new series of HAPs as anti-HBV agents targeting at capsid assembly

Bioorganic & Medicinal Chemistry Letters
2014.0

Abstract

A series of novel Heteroaryldihydropyrimidines (HAPs) derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly. These compounds were prepared from efforts to optimize an earlier series of HAPs, and compounds Mo1, Mo7, Mo8, Mo10, Mo12, and Mo13 demonstrated potent inhibition of HBV DNA replication at submicromolar range.

Knowledge Graph

Similar Paper

A new series of HAPs as anti-HBV agents targeting at capsid assembly
Bioorganic & Medicinal Chemistry Letters 2014.0
2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1H)-one derivatives as anti-HBV agents targeting at capsid assembly
Bioorganic & Medicinal Chemistry Letters 2010.0
Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors
Bioorganic & Medicinal Chemistry Letters 2017.0
Discovery of Novel Pyrimidine-Based Capsid Assembly Modulators as Potent Anti-HBV Agents
Journal of Medicinal Chemistry 2021.0
Design, diversity-oriented synthesis and biological evaluation of novel heterocycle derivatives as non-nucleoside HBV capsid protein inhibitors
European Journal of Medicinal Chemistry 2020.0
Synthesis of sulfamoylbenzamide derivatives as HBV capsid assembly effector
European Journal of Medicinal Chemistry 2017.0
Discovery of hepatitis B virus capsid assembly inhibitors leading to a heteroaryldihydropyrimidine based clinical candidate (GLS4)
Bioorganic & Medicinal Chemistry 2017.0
Design, Synthesis, and Antihepatitis B Virus Activities of Novel 2-Pyridone Derivatives
Journal of Medicinal Chemistry 2010.0
Isolation, synthesis and anti-hepatitis B virus evaluation of p-hydroxyacetophenone derivatives from Artemisia capillaris
Bioorganic & Medicinal Chemistry Letters 2015.0
Design, synthesis and primary biological evaluation of the novel 2-pyridone derivatives as potent non-nucleoside HBV inhibitors
European Journal of Medicinal Chemistry 2017.0