Dibenzazecine scaffold rebuilding—Is the flexibility always essential for high dopamine receptor affinities?

Dibenzazecine scaffold rebuilding—Is the flexibility always essential for high dopamine receptor affinities? Dopamine/Serotonin Receptor Ligands. 9. Oxygen-Containing Midsized Heterocyclic Ring Systems and Nonrigidized Analogues. A Step toward Dopamine D₅ Receptor Selectivity Further Definition of the D₁ Dopamine Receptor Pharmacophore:  Synthesis of trans-6,6a,7,8,9,13b-Hexahydro-5H-benzo[d]naphth[2,1-b]azepines as Rigid Analogues of β-Phenyldopamine Dopamine/Serotonin Receptor Ligands. 10: SAR Studies on Azecine-type Dopamine Receptor Ligands by Functional Screening at Human Cloned D₁, D_2L, and D₅ Receptors with a Microplate Reader Based Calcium Assay Lead to a Novel Potent D₁/D₅ Selective Antagonist Evaluation of cis- and trans-9- and 11-Hydroxy-5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridines as Structurally Rigid, Selective D1 Dopamine Receptor Ligands Synthesis and evaluation of several cathechol bioisosteres as potential dopamine receptor ligands Rigid analogs of dopamine: synthesis and interaction of 6-exo- and 6-endo-(3',4'-dihydroxyphenyl)-2-azabicyclo[2.2.2]octanes with dopamine uptake sites and receptors Assessment of dopamine D1 receptor affinity and efficacy of three tetracyclic conformationally-restricted analogs of SKF38393 Facile synthesis of octahydrobenzo[h]isoquinolines: Novel and highly potent D1 dopamine agonists Conformational analysis and structure-activity relationships of selective dopamine D-1 receptor agonists and antagonists of the benzazepine series