Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases

Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases Design and synthesis of novel PRMT1 inhibitors and investigation of their binding preferences using molecular modelling Discovery of decamidine as a new and potent PRMT1 inhibitor Discovery and Mechanistic Study of a Class of Protein Arginine Methylation Inhibitors Development of rationally designed DNA N6 adenine methyltransferase inhibitors Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach Exploration of Cyanine Compounds as Selective Inhibitors of Protein Arginine Methyltransferases: Synthesis and Biological Evaluation Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors Discovery and structure–activity analysis of 4-((5-nitropyrimidin-4-yl)amino)benzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors Discovery of a Dual PRMT5–PRMT7 Inhibitor