Development of rationally designed DNA N6 adenine methyltransferase inhibitors

Development of rationally designed DNA N6 adenine methyltransferase inhibitors SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes Constrained (l-)-S-adenosyl-l-homocysteine (SAH) analogues as DNA methyltransferase inhibitors Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1 Toward the development of potent and selective bisubstrate inhibitors of protein arginine methyltransferases Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains¹ Synthesis and evaluation of some stable multisubstrate adducts as inhibitors of catechol O-methyltransferase Analogues of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis of analogues with modifications at the 5'-thioether linkage Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues