Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site

Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site The design and synthesis of novel α-ketoamide-based p38 MAP kinase inhibitors A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis Design, Synthesis, and Biological Evaluation of Novel Type I¹/₂ p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode Selective targeting of the αC and DFG-out pocket in p38 MAPK Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38α Inhibitors Two classes of p38α MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes Dibenzosuberones as p38 Mitogen-Activated Protein Kinase Inhibitors with Low ATP Competitiveness and Outstanding Whole Blood Activity Identification of Novel p38α MAP Kinase Inhibitors Using Fragment-Based Lead Generation