The design and synthesis of novel α-ketoamide-based p38 MAP kinase inhibitors

The design and synthesis of novel α-ketoamide-based p38 MAP kinase inhibitors Optimization of α-ketoamide based p38 inhibitors through modifications to the region that binds to the allosteric site A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode Targeting the Hinge Glycine Flip and the Activation Loop: Novel Approach to Potent p38α Inhibitors Two classes of p38α MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes Design, Synthesis, and Biological Evaluation of Novel Type I¹/₂ p38α MAP Kinase Inhibitors with Excellent Selectivity, High Potency, and Prolonged Target Residence Time by Interfering with the R-Spine Potent inhibitors of the MAP kinase p38 Design, Synthesis, and Biological Evaluation of Phenylamino-Substituted 6,11-Dihydro-dibenzo[b,e]oxepin-11-ones and Dibenzo[a,d]cycloheptan-5-ones:  Novel p38 MAP Kinase Inhibitors Dibenzosuberones as p38 Mitogen-Activated Protein Kinase Inhibitors with Low ATP Competitiveness and Outstanding Whole Blood Activity