InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

A simple and convenient method for the one-pot three-component synthesis of 3-pyranyl indoles has been accomplished by tandem Knoevenagel-Michael reaction of 3-cyanoacetyl indole, various aromatic aldehydes and malononitrile catalyzed by InCl(3) in ethanol under reflux conditions. The newly synthesized 3-pyranyl indoles were evaluated for anti-microbial, antioxidant, and anticancer activities. Some of the compounds showed good anticancer activity against MCF-7 breast cancer cell lines on comparison with of standard drug.

Knowledge Graph

Similar Paper

InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives
Bioorganic & Medicinal Chemistry Letters 2010.0
Indium(III) chloride catalyzed three-component coupling reaction: A novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2010.0
One-pot multicomponent synthesis and anti-microbial evaluation of 2′-(indol-3-yl)-2-oxospiro(indoline-3,4′-pyran) derivatives
Bioorganic & Medicinal Chemistry Letters 2010.0
InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents
Bioorganic & Medicinal Chemistry Letters 2012.0
Solvent-free, microwave assisted Knoevenagel condensation of novel 2,5-disubstituted indole analogues and their biological evaluation
European Journal of Medicinal Chemistry 2011.0
Synthesis of 3,3-diindolyl oxyindoles efficiently catalysed by FeCl3 and their in vitro evaluation for anticancer activity
Bioorganic & Medicinal Chemistry Letters 2010.0
An expeditious regioselective synthesis of novel bioactive indole-substituted chromene derivatives via one-pot three-component reaction
Bioorganic & Medicinal Chemistry Letters 2012.0
Iodine-catalyzed conjugate addition of indoles onto en-1,4-dione: A novel synthesis of 3-(1-(1H-indol-3-yl)-2-oxo-2-phenylethyl)indolin-2-ones as antibacterial and antifungal agents
Bioorganic & Medicinal Chemistry Letters 2011.0
Microwave solvent-free condition synthesis and pharmacological evaluation of pyrano[3,2-c]quinolines
Medicinal Chemistry Research 2012.0
Microwave-assisted synthesis of 3′-indolyl substituted 4H-chromenes catalyzed by DMAP and their antimicrobial activity
Medicinal Chemistry Research 2012.0