Effect of NlpE Overproduction on Multidrug Resistance in Escherichia coli

Antimicrobial Agents and Chemotherapy
2010.0

Abstract

NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps in Escherichia coli.

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