Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil

Antimicrobial Agents and Chemotherapy
2008.0

Abstract

Activity of simulated cefditoren urinary concentrations was determined against seven Escherichia coli isolates. Bactericidal activity was obtained from 4 to 24 h against TEM-1 (penicillinase production/hyperproduction), TEM-34 (IRT-6), and TEM-116 (extended-spectrum beta-lactamase [ESBL]) and from 6 to 8 h against SHV/TEM-116 (ESBL) but never against SHV/TEM-1 (ESBL). Extension of bactericidal activity depended on the resistance genotype/phenotype tested.

Knowledge Graph

Similar Paper

Urine Bactericidal Activity against Escherichia coli Isolates Exhibiting Different Resistance Phenotypes/Genotypes in an In Vitro Pharmacodynamic Model Simulating Urine Concentrations Obtained after Oral Administration of a 400-Milligram Single Dose of Cefditoren-Pivoxil
Antimicrobial Agents and Chemotherapy 2008.0
Influence of TEM-1 β-Lactamase on the Pharmacodynamic Activity of Simulated Total versus Free-Drug Serum Concentrations of Cefditoren (400 Milligrams) versus Amoxicillin-Clavulanic Acid (2,000/125 Milligrams) against Haemophilus influenzae Strains Exhibiting an N526K Mutation in the ftsI Gene
Antimicrobial Agents and Chemotherapy 2007.0
Activity of Temocillin against KPC-Producing Klebsiella pneumoniae and Escherichia coli
Antimicrobial Agents and Chemotherapy 2009.0
Oral and Parenteral Therapeutic Options for Outpatient Urinary Infections Caused byEnterobacteriaceaeProducing CTX-M Extended-Spectrum β-Lactamases
Antimicrobial Agents and Chemotherapy 2009.0
Impact of Low-Level Resistance to Fluoroquinolones Due to qnrA1 and qnrS1 Genes or a gyrA Mutation on Ciprofloxacin Bactericidal Activity in a Murine Model of Escherichia coli Urinary Tract Infection
Antimicrobial Agents and Chemotherapy 2009.0
Oral Treatment Options for Ambulatory Patients with Urinary Tract Infections Caused by Extended-Spectrum-β-Lactamase-Producing Escherichia coli
Antimicrobial Agents and Chemotherapy 2010.0
Bactericidal Activities of Meropenem and Ertapenem against Extended-Spectrum-β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae in a Neutropenic Mouse Thigh Model
Antimicrobial Agents and Chemotherapy 2007.0
Eradicating uropathogenic Escherichia coli biofilms with a ciprofloxacin–dinitroxide conjugate
MedChemComm 2019.0
In Vitro Activity of Tebipenem, a New Oral Carbapenem Antibiotic, against β-Lactamase-Nonproducing, Ampicillin-Resistant Haemophilus influenzae
Antimicrobial Agents and Chemotherapy 2010.0
Surveillance of Community-Based Reservoirs Reveals the Presence of CTX-M, Imported AmpC, and OXA-30 β-Lactamases in Urine Isolates of Klebsiella pneumoniae and Escherichia coli in a U.S. Community
Antimicrobial Agents and Chemotherapy 2008.0