The activities of tigecycline and eight other agents were evaluated against 220 coryneform bacteria and 42 Listeria monocytogenes isolates. All strains were inhibited by tigecycline at 0.5 mug/ml, except for 11 Corynebacterium striatum strains that were inhibited at 1 mug/ml. Tigecycline shows good in vitro activity against coryneform bacteria and L. monocytogenes.