Inhibitors selective for HDAC6 in enzymes and cells

Bioorganic & Medicinal Chemistry Letters
2010.0

Abstract

Histone deacetylase inhibitors with anticancer or anti-inflammatory activity bind to Class I or Class I and II HDAC enzymes. Here we compare selectivity of inhibitors of a Class II HDAC enzyme (HDAC6) and find one that retains high selectivity in macrophages.

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