Daptomycin Rapidly Penetrates a Staphylococcus epidermidis Biofilm

Antimicrobial Agents and Chemotherapy
2009.0

Abstract

Fluorescently tagged daptomycin accessed the interior of Staphylococcus epidermidis biofilm cell clusters within minutes. The diffusion coefficient of daptomycin in the biofilm was 28% of its value in pure water. Daptomycin activity against staphylococci embedded in biofilms is unlikely to be limited by penetration of the antibiotic into the biofilm.

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