Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher’s disease

Synthesis of N-alkylated noeurostegines and evaluation of their potential as treatment for Gaucher’s disease Synthesis of potent β-D-glucocerebrosidase inhibitors: N-alkyl-β-valienamines (5aR)-5a-C-Pentyl-4-epi-isofagomine: A powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp2-iminosugar conjugates against glycosidases: A structure–activity relationship study in Gaucher fibroblasts Docking and SAR studies of calystegines: Binding orientation and influence on pharmacological chaperone effects for Gaucher’s disease Selenoureido-iminosugars: A new family of multitarget drugs trans, trans-2-C-Aryl-3,4-dihydroxypyrrolidines as potent and selective β-glucosidase inhibitors: Pharmacological chaperones for Gaucher disease Fluorinated Chaperone−β-Cyclodextrin Formulations for β-Glucocerebrosidase Activity Enhancement in Neuronopathic Gaucher Disease Evaluation of Quinazoline Analogues as Glucocerebrosidase Inhibitors with Chaperone Activity Docking and SAR studies of d- and l-isofagomine isomers as human β-glucocerebrosidase inhibitors