Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity

Bioorganic & Medicinal Chemistry
2011.0

Abstract

A library of 1,4-benzodiazepines has been synthesized and evaluated against Trypanosoma brucei, a causative parasite of Human African trypanosomiasis. Benzodiazepines possessing a P2- transporter motif were found to have MIC values as low as 0.78 μM.

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