Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

The synthesis and antibacterial activity of 3-(4-([1,2,4]triazolo[4,3-a]pyrimidin-3-yl)phenyl)oxazolidin-2-ones is reported. Thiocarbonyl derivatives were found to be potent inhibitors of gram-positive pathogens and compound 4l was two to fourfold more potent than Linezolid.

Knowledge Graph

Similar Paper

Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and in vitro activity of novel 1,2,4-triazolo[4,3-a]pyrimidine oxazolidinone antibacterial agents. Part II
Bioorganic & Medicinal Chemistry Letters 2011.0
Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2013.0
Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives
Bioorganic & Medicinal Chemistry Letters 2005.0
Synthesis and antibacterial activity of arylpiperazinyl oxazolidinones with diversification of the N-substituents
Bioorganic & Medicinal Chemistry Letters 2004.0
Synthesis and antibacterial activity of novel 5-(4-methyl-1H-1,2,3-triazole) methyl oxazolidinones
European Journal of Medicinal Chemistry 2009.0
Synthesis and in vitro activity of novel isoxazolyl tetrahydropyridinyl oxazolidinone antibacterial agents
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and in vitro/in vivo antibacterial activity of oxazolidinones having thiocarbamate at C-5 on the A-ring and an amide- or urea-substituted [1,2,5]triazepane or [1,2,5]oxadiazepane as the C-ring
European Journal of Medicinal Chemistry 2013.0
The synthesis and antibacterial activity of 1,3,4-Thiadiazole phenyl oxazolidinone analogues
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis and antibacterial activity of some aryloxy/thioaryloxy oxazolidinone derivatives
Bioorganic & Medicinal Chemistry Letters 2004.0