Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules

Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules Synthesis and evaluation of C2 functionalized analogs of the α-tubulin-binding natural product pironetin Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with Tubulin Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2' configurations Relationships between the structure of taxol analogs and their antimitotic activity Antitumor agents. 139. Synthesis and biological evaluation of thiocolchicine analogs 5,6-dihydro-6(S)-acyloxy)- and 5,6-dihydro-6(S)-[(aroyloxy)methyl]-1,2,3-trimethoxy-9-(methylthio)-8H-cyclohepta[a]naphthalen-8-ones as novel cytotoxic and antimitotic agents Structure-antitubulin activity relationships in steganacin congeners and analogs. Inhibition of tubulin polymerization in vitro by (.+-.)-isodeoxypodophyllotoxin New synthetic inhibitors of microtubule depolymerization Synthesis and Antiproliferative Activities of Ottelione A Analogues