New synthetic inhibitors of microtubule depolymerization

Bioorganic & Medicinal Chemistry Letters
1998.0

Abstract

A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found. By structure-activity optimizations, compounds stabilizing microtubules much better than paclitaxel while showing a remarkably reduced cytotoxic activity were obtained. This dissoziation will open completely new therapeutic areas.

Knowledge Graph

Similar Paper

New synthetic inhibitors of microtubule depolymerization
Bioorganic & Medicinal Chemistry Letters 1998.0
Structure–activity relationships study at the 3′-N position of paclitaxel. part 2: synthesis and biological evaluation of 3′-N-thiourea- and 3′-N-thiocarbamate-bearing paclitaxel analogues
Bioorganic & Medicinal Chemistry Letters 2000.0
Relationships between the structure of taxol analogs and their antimitotic activity
Journal of Medicinal Chemistry 1991.0
Synthesis of novel taxol analogs and evaluation of their biological activities
Bioorganic & Medicinal Chemistry Letters 1997.0
Synthesis of biologically active 2-benzoyl paclitaxel analogues
Bioorganic & Medicinal Chemistry Letters 1995.0
Recent advances in microtubule-stabilizing agents
European Journal of Medicinal Chemistry 2018.0
Synthesis and biological evaluation of 4-Deacetoxy-1,7-dideoxy azetidine paclitaxel analogues
Bioorganic & Medicinal Chemistry Letters 2003.0
Synthesis of 2-O-heteroaroyl taxanes: evaluation of microtubule assembly promotion and cytotoxicity
Bioorganic & Medicinal Chemistry Letters 1995.0
Biologically active taxol analogs with deleted A-ring side chain substituents and variable C-2' configurations
Journal of Medicinal Chemistry 1991.0
Novel Biologically Active Taxol Analogues: Baccatin III 13-(N-(p-chlorobenzoyl)-(2′R,3′S)-3′-phenylisoserinate) and Baccatin III 13-(N-benzoyl-(2′R,3′S)-3′-(p-chlorophenyl)isoserinate)
Bioorganic & Medicinal Chemistry Letters 1992.0