Efficient synthesis, structural characterization and anti-microbial activity of chiral aryl boronate esters of 1,2- O -isopropylidene-α- d -xylofuranose

Bioorganic & Medicinal Chemistry Letters
2011.0

Abstract

A simple and efficient synthetic approach toward a series of chiral aryl boronate esters, starting from D-xylose, as anti-microbial agents, is described herein. Minimum inhibitory concentration and zone of inhibition revealed that these derivatives exhibit potent anti-bacterial and anti-fungal properties. Herein, we report the first anti-microbial activity of this class of compounds. All products have been characterized by NMR ((1)H, (13)C and (11)B), IR, elemental and mass spectral study.

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