As part of a hit generation effort to discover new T. cruzi inhibitors, a diversity set of agrochemicals was screened in vitro in a whole cell parasite assay against a T. cruzi strain (Tulahuen) belonging to T. cruzi group VI (TcVI) [1] and transfected with the Lac-Z gene. [2] The plant fungicides fenarimol [DNDI1246778] and pyrifenox [DNDI1255613], used in the control of powdery mildew and fungus on fruits and vegetables, demonstrated good activity in the assay with IC50's of 350 nM and 290 nM, respectively. With simple aromatic components and modular synthesis, fenarimol was an ideal starting point for structure-activity-relationship (SAR) investigations aimed at improving activity against T. cruzi and developing compounds suitable for in vivo characterisation.