Structure-based design of isoindoline-1,3-diones and 2,3-dihydrophthalazine-1,4-diones as novel B-Raf inhibitors

Structure-based design of isoindoline-1,3-diones and 2,3-dihydrophthalazine-1,4-diones as novel B-Raf inhibitors Design and synthesis of isoquinolines and benzimidazoles as RAF kinase inhibitors Design, synthesis, and biological evaluation of new B-RafV600E kinase inhibitors Dual binding site inhibitors of B-RAF kinase Design and Synthesis of Orally Bioavailable Benzimidazoles as Raf Kinase Inhibitors Novel Inhibitors of B-RAF Based on a Disubstituted Pyrazine Scaffold. Generation of a Nanomolar Lead The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors Conformation-Specific Effects of Raf Kinase Inhibitors Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors Design and Optimization of Potent and Orally Bioavailable Tetrahydronaphthalene Raf Inhibitors