A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions

European Journal of Medicinal Chemistry
2012.0

Abstract

In the present report, a concise synthesis of viscolin (1) has been achieved. The anti-inflammatory effect of viscolin was investigated in vitro and in vivo. Viscolin blocked the expression of iNOS and COX-2, and it also inhibited the ERK for the activation of NF-κB in LPS-stimulated RAW 264.7 macrophages. Western blotting and immunohistochemical analysis revealed that viscolin decreased Carr-induced iNOS and COX-2 expressions. These results could help to deduce the anti-inflammatory mechanisms.

Knowledge Graph

Similar Paper

A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions
European Journal of Medicinal Chemistry 2012.0
Total synthesis and biological evaluation of viscolin, a 1,3-diphenylpropane as a novel potent anti-inflammatory agent
Bioorganic & Medicinal Chemistry Letters 2006.0
Anti-Inflammatory Effects of Trilinolein from<i>Panax notoginseng</i>Through the Suppression of NF-κB and MAPK Expression and Proinflammatory Cytokine Expression
The American Journal of Chinese Medicine 2014.0
Vermelhotin, an Anti-inflammatory Agent, Suppresses Nitric Oxide Production in RAW 264.7 Cells via p38 Inhibition
Journal of Natural Products 2013.0
Fraxinellone Inhibits Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression by Negatively Regulating Nuclear Factor-kappa B in RAW 264.7 Macrophages Cells
Biological and Pharmaceutical Bulletin 2009.0
Casticin inhibits COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages
Journal of Ethnopharmacology 2014.0
Inhibitory effect of resveratrol dimerized derivatives on nitric oxide production in lipopolysaccharide-induced RAW 264.7 cells
Bioorganic &amp; Medicinal Chemistry Letters 2013.0
Synthesis and anti-inflammatory effects of a series of novel 7-hydroxycoumarin derivatives
European Journal of Medicinal Chemistry 2011.0
Oroxylin A inhibition of lipopolysaccharide-induced iNOS and COX-2 gene expression via suppression of nuclear factor-κB activation
Biochemical Pharmacology 2000.0
Sclareol Exhibits Anti-inflammatory Activity in Both Lipopolysaccharide-Stimulated Macrophages and the λ-Carrageenan-Induced Paw Edema Model
Journal of Natural Products 2012.0