Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model

MedChemComm
2011.0

Abstract

The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.

Knowledge Graph

Similar Paper

Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model
MedChemComm 2011.0
Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin
Bioorganic & Medicinal Chemistry Letters 2006.0
Conjugated Chitosan as a Novel Platform for Oral Delivery of Paclitaxel
Journal of Medicinal Chemistry 2008.0
Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: Evaluation of novel conjugates as cytotoxic agents
Bioorganic & Medicinal Chemistry Letters 2007.0
Synthesis of Paclitaxel–BGL Conjugates
Bioorganic & Medicinal Chemistry 2012.0
Paclitaxel C-10 carbamates: Potential candidates for the treatment of neurodegenerative tauopathies
Bioorganic & Medicinal Chemistry Letters 2007.0
Synthesis and antitumor evaluation of 2′-oxycarbonylpaclitaxels (paclitaxel-2′-carbonates)
Bioorganic & Medicinal Chemistry Letters 1994.0
Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant—taxoid conjugates as novel cytotoxic agents
Bioorganic & Medicinal Chemistry Letters 2007.0
Paclitaxel succinate analogs: Anionic and amide introduction as a strategy to impart blood–brain barrier permeability
Bioorganic & Medicinal Chemistry Letters 2008.0
Novel second generation analogs of eribulin. Part III: Blood–brain barrier permeability and in vivo activity in a brain tumor model
Bioorganic & Medicinal Chemistry Letters 2011.0