Pharmacokinetics of Agelastatin A in the central nervous system

Pharmacokinetics of Agelastatin A in the central nervous system An integrated approach to the discovery of potent agelastatin A analogues for brain tumors: chemical synthesis and biological, physicochemical and CNS pharmacokinetic analyses Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe Structure-Activity Relationship of .alpha.-Galactosylceramides against B16-Bearing Mice A Virtual Screening Platform Identifies Chloroethylagelastatin A as a Potential Ribosomal Inhibitor Agelastatin a, a new skeleton cytotoxic alkaloid of the oroidin family. Isolation from the axinellid sponge Agelas dendromorpha of the coral sea Synthesis and Evaluation of Agelastatin Derivatives as Potent Modulators for Cancer Invasion and Metastasis Potent Fluorinated Agelastatin Analogues for Chronic Lymphocytic Leukemia: Design, Synthesis, and Pharmacokinetic Studies Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.