Synthesis and antidepressant activity of di substituted-5-aryl-1,2,4-triazoles

Medicinal Chemistry Research
2012.0

Abstract

A series of 5-aryl-1H-1,2,4-triazole-3-thiol (3) were synthesized. Alkylation of thiol group with N,Ndimethyl/diethyl/dicyclo hexyl-(2-chloro ethyl) amine gave compounds N,N-disubstituted-2-(5-aryl-1H-1,2,4-triazol-3 ylthio)ethanamine (4). These compounds were characterized on the basis of IR, 1 H NMR, Mass spectral data, and elemental analysis. The newly synthesized compounds were screened for their antidepressant activity by using tail suspension test in mice.

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