Selenophene-Containing Inhibitors of Type IIA Bacterial Topoisomerases

Selenophene-Containing Inhibitors of Type IIA Bacterial Topoisomerases Design, Synthesis, and Characterization of Novel Tetrahydropyran-Based Bacterial Topoisomerase Inhibitors with Potent Anti-Gram-Positive Activity Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV Novel N-Linked Aminopiperidine Inhibitors of Bacterial Topoisomerase Type II with Reduced pK_a: Antibacterial Agents with an Improved Safety Profile Left-Hand Side Exploration of Novel Bacterial Topoisomerase Inhibitors to Improve Selectivity against hERG Binding Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety Novel bacterial topoisomerase inhibitors derived from isomannide Novel 3-fluoro-6-methoxyquinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA New Alkaloid Antibiotics That Target the DNA Topoisomerase I of Streptococcus pneumoniae