4-Substituted-2-phenylquinazolines as inhibitors of BCRP

Bioorganic & Medicinal Chemistry Letters
2012.0

Abstract

We investigated several 2-phenylquinazolines with different substitutions at position 4 for their BCRP inhibition. Compounds with phenyl ring attached via an amine-containing linker at position 4 were found to be potent inhibitors of BCRP. In general compounds with meta substitution of phenyl ring at position 4 were found to have higher inhibitory effect, compound 12 being the most potent and selective towards BCRP.

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