Inhibition of Human Topoisomerases I and II by Simocyclinone D8

Inhibition of Human Topoisomerases I and II by Simocyclinone D8 In Vivo and In Vitro Patterns of the Activity of Simocyclinone D8, an Angucyclinone Antibiotic from <i>Streptomyces antibioticus</i> Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tue 6040. I. Taxonomy, Fermentation, Isolation and Biological Activities. Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tue 6040. II. Structure Elucidation and Biosynthesis. New naphthacenecarboxamide antibiotics, TAN-1518 A and B, have inhibitory activity against mammalian DNA topoisomerase I. Pyrroloquinolinone-based dual topoisomerase I/II inhibitor SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520. I. Taxonomy, Fermentation, Isolation and Biological Activities. BN 80927: A novel homocamptothecin with inhibitory activities on both topoisomerase I and topoisomerase II Topoisomerase II inhibitors. Synthetic hybridization of 4-quinolones and anthracyclines