Enantiomerically Pure 1,3-Dioxanes as Highly Selective NMDA and σ₁Receptor Ligands

Enantiomerically Pure 1,3-Dioxanes as Highly Selective NMDA and σ₁Receptor Ligands Novel PotentN-Methyl-<scp>d</scp>-aspartate (NMDA) Receptor Antagonists or σ₁Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring Synthesis of conformationally restricted 1,3-dioxanes to analyze the bioactive conformation of 1,3-dioxane-based σ 1 and PCP receptor antagonists Synthesis of 4-(aminoalkyl) substituted 1,3-dioxanes as potent NMDA and σ receptor antagonists Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ1 receptor affinity, antitumor and analgesic activity Synthesis and NMDA receptor affinity of dexoxadrol analogues with modifications in position 4 of the piperidine ring Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes From NMDA receptor antagonists to discovery of selective σ2 receptor ligands Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity (+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties