Chiral γ-Aryl-1H-1,2,4-triazole Derivatives as Highly Potential Antifungal Agents: Design, Synthesis, Structure, and in Vitro Fungicidal Activities

Journal of Agricultural and Food Chemistry
2008.0

Abstract

A novel series of chiral gamma-aryl-1H-1,2,4-triazole derivatives as highly potential antifungal agents have been designed and synthesized conveniently by using the chiral auxiliary as a controlling reagent. All of the compounds exhibit moderate to high ee values reaching up to 99%, and the preliminary bioassay results demonstrated that most of the target compounds take on a significantly wide spectrum activity against Fusarium oxysporium, Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Dothiorella gregaria, and Colletotrichum gossypii species.

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