Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF

Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF Structure–Activity Relationships Among the Nitrogen Containing Bisphosphonates in Clinical Use and Other Analogues: Time-Dependent Inhibition of Human Farnesyl Pyrophosphate Synthase Cytidine derivatives as IspF inhibitors of Burkolderia pseudomallei Isoprenoid Biosynthesis as a Drug Target:  Bisphosphonate Inhibition of Escherichia coli K12 Growth and Synergistic Effects of Fosmidomycin Novel bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase Pyridinium-1-yl Bisphosphonates Are Potent Inhibitors of Farnesyl Diphosphate Synthase and Bone Resorption A synthetic diphosphoinositol phosphate analogue of inositol trisphosphate Determination of the Microscopic Equilibrium Dissociation Constants for Risedronate and Its Analogues Reveals Two Distinct Roles for the Nitrogen Atom in Nitrogen-Containing Bisphosphonate Drugs Bisphosphonates target multiple sites in both cis - and trans -prenyltransferases Design of potent bisphosphonate inhibitors of the human farnesyl pyrophosphate synthase via targeted interactions with the active site ‘capping’ phenyls