Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids

Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids Chemistry and antitumor evaluation of selected classical 2,4-diaminoquinazoline analogs of folic acid Synthesis of quinazoline analogs of folic acid modified at position 10 Synthesis of 5-chloro-5,8-dideaza analogs of folic acid and aminopterin targeted for colon adenocarcinoma Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogs 2,4-Diamino-5-chloroquinazoline Analogs of Trimetrexate and Piritrexim: Synthesis and Antifolate Activity Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogs of folic acid and aminopterin Folate analogs. 21. Synthesis and antifolate and antitumor activities of N10-(cyanomethyl)-5,8-dideazafolic acid Syntheses and antifolate activity of 5-methyl-5-deaza analogs of aminopterin, methotrexate, folic acid, and N10-methylfolic acid Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogs of folic acid and aminopterin bearing a terminal L-ornithine