Discovery of DF-461, a Potent Squalene Synthase Inhibitor

Discovery of DF-461, a Potent Squalene Synthase Inhibitor Phenoxypropylamines: A New Series of Squalene Synthase Inhibitors Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity Design of Novel Potent Antihyperlipidemic Agents with Antioxidant/Anti-inflammatory Properties: Exploiting Phenothiazine’s Strong Antioxidant Activity Discovery of triazines as potent, selective and orally active PDE4 inhibitors Squalene analogs containing isopropylidene mimics as potential inhibitors of pig liver squalene epoxidase and oxidosqualene cyclase Synthesis of 4-trifluoromethylsteroids: A novel class of steroid 5α-reductase inhibitors Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors Synthesis of a novel series of 2-alkylthio substituted naphthoquinones as potent acyl-CoA: Cholesterol acyltransferase (ACAT) inhibitors Synthesis and pharmacological evaluation of substituted 5-[4-[2-(6,7-dimethyl-1,2,3,4-tetrahydro-2-oxo-4-quinoxalinyl)ethoxy]phenyl]methylene]thiazolidine-2,4-dione derivatives as potent euglycemic and hypolipidemic agents