Discovery of triazines as potent, selective and orally active PDE4 inhibitors

Discovery of triazines as potent, selective and orally active PDE4 inhibitors Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors Identification of a potent new chemotype for the selective inhibition of PDE4 Synthesis and bioactivity of pyrazole and triazole derivatives as potential PDE4 inhibitors Optimization of purine based PDE1/PDE5 inhibitors to a potent and selective PDE5 inhibitor for the treatment of male ED Identification of 2,3-disubstituted pyridines as potent, orally active PDE4 inhibitors Design and synthesis of 4,5,6,7‐tetrahydro‐1 H ‐1,2‐diazepin‐7‐one derivatives as a new series of Phosphodiesterase 4 (PDE4) inhibitors Design, Synthesis, and Pharmacological Evaluation ofN-Acylhydrazones and Novel Conformationally Constrained Compounds as Selective and Potent Orally Active Phosphodiesterase-4 Inhibitors Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands Synthesis and structure–activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1- hi ]indoles: novel PDE4 inhibitors