Literature

Abstract

The propargyl alcohol on reaction with aldoxime and NaOCl in DCM gave exclusively (3-arylisoxazol-5-yl) methanol 1. The compound 1 was oxidized to an aldehyde 2 followed by reaction with aniline resulted in Schiff's base 3. The compounds 3 were further reacted with various aldehydes having α-hydrogen using molecular iodine as catalyst and which yielded 5-(3-alkylquinolin-2-yl)-3-aryl isoxazole derivatives 4. All the final compounds 4 were screened against four human cancer cell lines (A549, COLO 205, MDA-MB 231 and PC-3) and among these compounds 4n showed potent cytotoxicity against all the cell lines at IC50 values of <12 μM.

DOI： 10.1016/j.bmcl.2014.01.038

Synthesis of novel 5-(3-alkylquinolin-2-yl)-3-aryl isoxazole derivatives and their cytotoxic activity

Bioorganic & Medicinal Chemistry Letters 2014.0

Synthesis of novel 2-alkyl triazole-3-alkyl substituted quinoline derivatives and their cytotoxic activity

Bioorganic & Medicinal Chemistry Letters 2013.0

Synthesis of novel 1,2,3-triazole/isoxazole functionalized 2H-Chromene derivatives and their cytotoxic activity

Bioorganic & Medicinal Chemistry Letters 2014.0

Synthesis and cytotoxicity of novel 6H-indolo[2,3-b]quinoxaline derivatives

Medicinal Chemistry Research 2013.0

Iodine mediated pyrazolo-quinoline derivatives as potent anti-proliferative agents

Bioorganic & Medicinal Chemistry Letters 2018.0

Synthesis of new chromeno-annulated cis-fused pyrano[4,3-c]isoxazole derivatives via intramolecular nitrone cycloaddition and their cytotoxicity evaluation