Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl-guanidines at the four histamine receptor subtypes: a bioisosteric approach

Synthesis, SAR and selectivity of 2-acyl- and 2-cyano-1-hetarylalkyl-guanidines at the four histamine receptor subtypes: a bioisosteric approach Synthesis and Structure−Activity Relationships of Cyanoguanidine-Type and Structurally Related Histamine H₄Receptor Agonists Acylguanidines as Bioisosteres of Guanidines:N^G-Acylated Imidazolylpropylguanidines, a New Class of Histamine H₂Receptor Agonists N^G-Acylated Imidazolylpropylguanidines as Potent Histamine H₄Receptor Agonists: Selectivity by Variation of theN^G-Substituent Conformational Restriction and Enantioseparation Increase Potency and Selectivity of Cyanoguanidine-Type Histamine H₄Receptor Agonists Chiral NG-acylated hetarylpropylguanidine-type histamine H2 receptor agonists do not show significant stereoselectivity Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H₄ Receptor Affinity and Subtly Govern H₄/H₃ Subtype Selectivity Bioisosteric prototype design of biaryl imidazolyl and triazolyl competitive histamine H2-receptor antagonists Abolishing Dopamine D_2long/D₃ Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H₂ Receptor Agonists A Selective Human H₄-Receptor Agonist:  (−)-2-Cyano-1-methyl-3-{(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-yl}methylguanidine