Nitrones. 7. .alpha.-Quinoxalinyl-N-substituted nitrone 1,4-dioxides

Journal of Medicinal Chemistry
1977.0

Abstract

A series of alpha-quinoxalinyl-N-substitute nitrone 1,4-dioxides has been synthesize and evaluated as antibacterial and antiprotozoal agents. Structure-activity relationships are discussed. Of the compounds tested, alpha-(3-methyl-2-quinoxalinyl)-N-methylnitrone 1,4-dioxide (2) was the most active agent in vivo against the gram-negative and the gram-positive organisms.

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