Design and synthesis of new vancomycin derivatives

Bioorganic & Medicinal Chemistry Letters
2014.0

Abstract

A set of vancomycin derivatives with lipid chain attached via a glyceric acid linker was designed and synthesized. A concise synthesis towards these derivatives was developed and the IC50s of these new lipoglycopeptides were tested. Some of them showed very potent activity against both vancomycin sensitive and resistant strains.

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