Experiments on the synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analogues

Journal of Medicinal Chemistry
1976.0

Abstract

Several dl-camptothecin analogues in which the ethyl group in the E ring of the parent compound 1 is replaced by other side chains were synthesized and their life-span activity in L1210 leukemic mice was tested. dl-Desethylallylcamptothecin (13) was more active than dl-camptothecin and others.

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