Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors

Structure-Based Design of Potent and Selective Leishmania N-Myristoyltransferase Inhibitors Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP) Kinetics and docking studies of two potential new inhibitors of the nucleoside hydrolase from Leishmania donovani Design, Synthesis, and Evaluation of Inhibitors of Trypanosomal and Leishmanial Dihydrofolate Reductase Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N -myristoyltransferase. Part 1 Synthesis of five libraries of 6,5-fused heterocycles to establish the importance of the heterocyclic core for antiplasmodial activity Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors Structure based medicinal chemistry-driven strategy to design substituted dihydropyrimidines as potential antileishmanial agents Inhibitors of Leishmania GDP-Mannose Pyrophosphorylase Identified by High-Throughput Screening of Small-Molecule Chemical Library