Discovery of pyrrolo-benzo-1,4-diazines as potent Nav1.7 sodium channel blockers

Discovery of pyrrolo-benzo-1,4-diazines as potent Nav1.7 sodium channel blockers Imidazopyridines: A novel class of hNav1.7 channel blockers A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain Substituted Indazoles as Na_v1.7 Blockers for the Treatment of Pain Discovery of Potent, Selective, and State-Dependent Na_V1.7 Inhibitors with Robust Oral Efficacy in Pain Models: Structure–Activity Relationship and Optimization of Chroman and Indane Aryl Sulfonamides Discovery of a biarylamide series of potent, state-dependent NaV1.7 inhibitors Synthesis and SAR of 4-aminocyclopentapyrrolidines as N-type Ca2+ channel blockers with analgesic activity 2,4(5)-Diarylimidazoles: Synthesis and biological evaluation of a new class of sodium channel blockers against hNav1.2 Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent Na_V1.7 inhibitors