A novel benzazepinone sodium channel blocker with oral efficacy in a rat model of neuropathic pain

Bioorganic & Medicinal Chemistry Letters
2013.0

Abstract

A series of benzazepinones were synthesized and evaluated for block of Nav1.7 sodium channels. Compound 30 from this series displayed potent channel block, good selectivity versus other targets, and dose-dependent oral efficacy in a rat model of neuropathic pain.

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