Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors

Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Heat Shock Protein 90 Tricyclic Series of Heat Shock Protein 90 (Hsp90) Inhibitors Part I: Discovery of Tricyclic Imidazo[4,5-c]pyridines as Potent Inhibitors of the Hsp90 Molecular Chaperone Discovery and development of heat shock protein 90 inhibitors Dihydroxyphenylisoindoline Amides as Orally Bioavailable Inhibitors of the Heat Shock Protein 90 (Hsp90) Molecular Chaperone N-Aryl-benzimidazolones as novel small molecule HSP90 inhibitors Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-Containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-Amino-4-{4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide Structure-based discovery of a new class of Hsp90 inhibitors Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents