Synthesis and biological evaluation of C-13′ substituted 7′- homo -anhydrovinblastine derivatives

Bioorganic & Medicinal Chemistry Letters
2015.0

Abstract

Recent publications highlighted that vinca derivatives either functionalized on C-12' or enlarged on cycle C' could be more cytotoxic than vinblastine or vinorelbine, both used in anti-cancer therapy. By combining these two results, nine new 7'-homo-anhydrovinblastine derivatives functionalized on C-13' were elaborated. The synthesis of key intermediates, their one-step transformation into final products in mild conditions and their biological activities are presented.

Knowledge Graph

Similar Paper