Synthesis of new 4-phenylpyrimidine-2(1 H )-thiones and their potency to inhibit COX-1 and COX-2

European Journal of Medicinal Chemistry
2015.0

Abstract

Several new 4-phenylpyrimidine-2(1H)-thiones have been prepared and investigated for their potencies to inhibit COX-1 and COX-2 enzymes, and COX-2 expression in THP-1 cells. Structure-activity-relationships and physicochemical parameters are discussed. Pharmacophore screening and docking studies were carried out for the most active compound.

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