Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation

Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl)phenyl)acetyl)piperazin-1-yl)ethyl)isobenzofuran-1(3H)-one Discovery of MK-7145, an Oral Small Molecule ROMK Inhibitor for the Treatment of Hypertension and Heart Failure Discovery of Small Molecule Renal Outer Medullary Potassium (ROMK) Channel Inhibitors: A Brief History of Medicinal Chemistry Approaches To Develop Novel Diuretic Therapeutics The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores Synthesis and Diuretic Activity of Alkyl- and Arylguanidine Analogs of N,N'-Dicyclohexyl-4-morpholinecarboxamidine in Rats and Dogs Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A 1 receptor antagonists and their biological evaluation The SAR of UK-78,282: A novel blocker of human T cell Kv1.3 potassium channels