Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction

Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein–Protein Interaction A Specific Mechanism of Nonspecific Inhibition Small-molecule aggregates inhibit amyloid polymerization Mechanisms of Specific versus Nonspecific Interactions of Aggregation-Prone Inhibitors and Attenuators Protein Stability Effects in Aggregate-Based Enzyme Inhibition Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding Inhibition of Protein−Protein Association by Small Molecules:  Approaches and Progress The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-α production Discovery of Selective Small-Molecule Inhibitors for the β-Catenin/T-Cell Factor Protein–Protein Interaction through the Optimization of the Acyl Hydrazone Moiety C-Phycocyanin from Spirulina Inhibits α-Synuclein and Amyloid-β Fibril Formation but Not Amorphous Aggregation