Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist

Synthesis and biological evaluation of pyrimidine derivatives with diverse azabicyclic ether/amine as novel GPR119 agonist Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists Synthesis and biological evaluation of 5-nitropyrimidine analogs with azabicyclic substituents as GPR119 agonists Design and synthesis of novel pyrimido[5,4-d]pyrimidine derivatives as GPR119 agonist for treatment of type 2 diabetes Synthesis and biological evaluation of novel 2,4-disubstituted quinazoline analogues as GPR119 agonists Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists Discovery of novel pyrrole derivatives as potent agonists for the niacin receptor GPR109A Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835 Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an Antidiabetic Clinical Candidate Targeting GPR119 Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a